What is the use of Antiresusive immunoglobulin

What is the use of "Antiresusive immunoglobulin"?

In the blood of Rh-positive people presenta specific protein that is found on red blood cells. 15% of the world's population are Rh-negative, because they do not have this protein. Rhesus factor is an individual trait transmitted by inheritance, but it has no effect on human health.

Usually the Rh component belongs to the blood group in the laboratory.

What is Rhesus Conflict?

This phenomenon worries women with negativeRhesus with blood. During pregnancy, a conflict can occur between the mother and the fetus, provided that the child has inherited Rh-positive blood from the father.

Normally, the blood of the mother and fetus is neveris mixed, but placental abnormalities and injuries can cause fetal red blood cells to enter the woman's bloodstream. When a certain "concentration threshold" is reached, the mother's immune system begins to produce antibodies against the foreign protein (it is the Rh factor on the fetal erythrocytes) for destruction, i.e., destruction of fetal blood. As a result, hemolytic disease occurs in the child. Sometimes the conflict can be so strong that there are malformations of the formation of the nervous system.

The probability of developing such a phenomenon is not sothe first pregnancy (if there are no pathologies) most often ends safely, but each subsequent pregnancy increases the risk of conflict development by 10-15%.

Antibodies can also form after abortion,miscarriage, ectopic pregnancy, Caesarean section and placental abruption. The likelihood of sensitization depends on the number of red blood cells of the fetus that have got into the mother's body.

How to prevent Rhesus-conflict?

Although for the health of the mother Rh-conflict is notrepresents the danger, the consequences of hemolytic disease for the baby are very difficult, so it is worthwhile to prevent this phenomenon in all women who have blood, a negative Rh-factor.

So, all pregnant women are assigned to carry out a blood test in the early stages of pregnancy to determine the Rh rhesus. The further algorithm of actions depends on the situation.

Usually the first pregnancy is normal.Throughout the term it is necessary to determine the level of antiresusive antibodies in a woman's blood. Up to 32 weeks, the blood is checked once a month, up to 35 weeks - 2 times a month, and then every week. While antibodies should not be. If a Rh-positive baby is born, then the mother must necessarily introduce the drug "Antiresusive immunoglobulin" in the first 72 hours after childbirth. Such a measure on allows the appearance of antibodies to the Rh factor. This is necessary to maintain and normal course of subsequent pregnancy.

If an abortion, a miscarriage or an abruption of the placenta, this is also an indication to introduce "Antirezus immunoglobulin".

Conflict in the Rh factor in the first pregnancy can be associated with a previously transfused positive blood to a woman who has a Rh negative.

How does the drug "Antiresusive immunoglobulin" work?

The substance prevents the formation of antibodies to the Rh factor, and hence, the appearance of hemolysis of erythrocytes in the fetus.

Most often the blood of a child enters the bloodstreammother occurs during childbirth, so the introduction of lekartsvennogo means "antiresusive immunoglobulin" is shown to a woman immediately after the appearance of the baby. This measure is not taken for a given child, but helps prevent the development of hemolytic disease during the next pregnancy. At the discretion of the doctor, it is possible to administer the drug also at the 28th week of pregnancy, if there is a risk of mixing two blood before delivery.

Contraindicated immunoglobulin antiresusive withrevealed sensitization (the presence of antibodies to the Rh factor in the blood of a pregnant woman), children, as well as women with Rh-positive blood. It can not be administered intravenously. Dosage depends on the amount of blood (namely erythrocytes) that has got into the mother's body.

An antiresusive immunoglobulin allows a woman with blood, negative for the Rh factor, to have as many children as she wants.

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